Bracanat 150mg tablet is an anticancer medicine prescribed in the treatment of ovarian, breast, pancreatic & prostate cancers. It inhibits the PARP enzyme, help repair single-strand DNA breaks. It works by reducing the number of viable cancer cells that helps to slow down the growth of tumor and may delay disease progression in eligible patients. Bracanat 150mg tablet mg is an PARP inhibitor contains Olaparib used after chemotherapy for the treatment of ovarian, breast, pancreatic & prostate cancers in patients with the BRCA mutation. It targets the DNA repair machinery of the malignant cells, thus controlling the growth and spread of the cancer. Bracanat 150mg Tablet is generally prescribed after a traditional chemotherapy process to prevent a relapse.
Bracanat 150mg (Olaparib) tablet is prescribed after chemotherapy to treat ovarian, breast, pancreatic & prostate cancers in patients with BRCA mutations or other homologous recombination repair (HRR) defects.
This cancer originates in the ovaries and closely related tissues. The ovarian cells normally go through a regular cycle of damage and repair. When mutations occur in the BRCA gene (genes responsible for the repair of damaged DNA) in the ovaries, this leads to unregulated cell division, which ultimately results in ovarian cancer. This type of cancer often remains asymptomatic in the initial stages, hence it is detected late. In this indication, Bracanat 150mg Tablet is typically given after chemotherapy (e.g., platinum-based chemotherapy). It prevents the relapse of cancer after the therapy.
Breast cancer refers to the uncontrolled cell division in the breast tissue and lymph nodes. Generally, these tumors depend on estrogen for growth, and thus, they possess the estrogen receptor (HER2-positive). However, in some cases, the cells are HER2-negative and have the BRCA mutated gene. Bracanat 150mg tablet is used in HER2-negative cancers, especially in advanced or metastatic cases. It specifically targets the BRCA mutant cancer cells and prevents any further growth of the tumor.
Pancreatic cancer is one of the most aggressive types of cancer and is often diagnosed late. Under pancreatic cancers, there is a subset of pancreatic cancer that manifests due to a mutation in the BRCA gene. Bracanat 150mg tablet is specifically used in the treatment of this subset of pancreatic cancer. It is generally administered after platinum-based chemotherapy. If there is no improvement in the disease even after 16 weeks of chemotherapy, Bracanat 150mg tablet is generally preferred. It controls the disease without the need for chemotherapy.
Prostate cancer arises in the prostate gland, and it generally depends on male hormones (e.g., androgens like testosterone) for growth. In advanced stages, it can spread to surrounding organs and lymph nodes, and can even continue to grow despite low testosterone levels. In these conditions, some tumor cells may develop the BRCA mutation, which cannot be treated easily. For this condition, Bracanat 150mg tablet is used to control the growth of the tumor.
This type of cancer arises in the fallopian tube and is biologically very similar to ovarian cancer. These cancers consist of the BRCA mutation, which drives the growth of the tumor. For these indications, Bracanat 150mg tablet is typically administered after chemotherapy to prevent the relapse of the disease.
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Bracanat 150mg tablet (Olaparib) is a targeted cancer treatment medication for certain types of cancers, particularly those with a mutation in a certain BRCA gene. The DNA requires regular repair as it can get damaged frequently during replication. There are dedicated DNA-repair pathways that are responsible for repairing the damaged DNA, and work by repairing double-stranded breaks (DSBs) in the DNA by the high-fidelity homologous recombination (HR) pathway.
In BRCA-mutated cancer cells, this HR pathway is present, but it is not functional. This prevents the accurate repair of DSBs in the damaged DNA. In order to survive, those cells rely on error-prone alternative methods of repair, such as Non-Homologous End Joining (NHEJ), which will lead to mutations and genomic instability, thereby promoting the development of cancer over time. Simultaneously, the PARP enzymes (PARP-1/2) repair Single-Strand Breaks (SSB) through base excision repair and serve as an important back-up mechanism for cell survival.
Bracanat 150mg tablet inhibits the PARP enzyme activity and also creates PARP trapping, where PARP remains connected with DNA and interferes with the DNA replication process, leading to accumulation of unrepaired SSBs and generation of DSB's during DNA replication. In normal cells, DSBs would be repaired through BRCA-mediated HR. However, in the case of BRCA-mutated cancer cells, this pathway is defective, and the back-up repair mechanisms become overwhelmed.
This leads to increased DNA damage, collapse of replication forks, chromosomal instability, and ultimately a halt in the cell cycle and cell death by apoptosis. This process is called synthetic lethality, where both repair pathways (BRCA + PARP) are damaged simultaneously and can selectively kill cancer cells while leaving normal cells unharmed.
Common side effects (very frequent)
–>Hematological (blood-related) effects
–>Gastrointestinal effects
–>Neurological/general effects
–>Musculoskeletal effects
–>Respiratory effects
–>Skin & hypersensitivity
–>Urinary & metabolic effects
(These are rare secondary bone marrow cancers, but they can be fatal)
Q. What is Bracanat 150mg tablet used for?
Bracanat 150mg tablet is used in the treatment of cancers with the BCRA mutation.
Q. How does Bracanat 150mg tablet work?
Bracanat 150mg tablet works by targeting the DNA repair machinery in cancer cells.
Q. What are the common side effects caused by Bracanat 150mg tablet?
Common side effects of Bracanat 150mg tablet include fatigue, infections, unusual bleeding, etc.
Q. Is Bracanat 150mg tablet a chemotherapy drug?
No. Bracanat 150mg tablet is a targeted therapy for BRCA-mutated cancers.
Q. Can pregnant women use Bracanat 150mg tablet ?
Bracanat 150mg tablet should not be consumed by pregnant women as it can harm the developing fetus.
