What is the Clexane 60 mg?

What is Clexane 60 mg

Clexane 60 mg consists of the drug enoxaparin, which is a low molecular weight heparin (LMWH). This drug is an anticoagulant and is typically used to prevent clot formation in certain indications and to prevent heart-related events. 

What are the Uses of Clexane 60 mg?

What are the Dosage Guidelines for Clexane 60 mg?

Clexane 60 mg is only used for indications where the dosage of Enoxaparin is based on the patient’s body weight. It is useful when the total calculated value of the drug to be administered, based on the patient’s body weight, is approximately equal to 60mg. 

Treatment of Deep Vein Thrombosis (± Pulmonary Embolism)

Recommended dose:

• 1 mg/kg of Enoxaparin every 12 hours OR
• 1.5 mg/kg of Enoxaparin once a day

Maximum dose limit:

• There is no strict dose limit for Clexane 60 mg for this indication, as the dosing is strictly weight-based.

Missed dose instructions: 

• In case of a missed dose, take the missed dose soon after remembering. If the time is close to the next dose, skip the missed dose and follow the normal schedule.

Overdose instructions: 

• Clinicians are recommended to use protamine sulfate in case of an overdose.

Unstable Angina / NSTEMI

Recommended dose:

• 1 mg/kg Enoxaparin every 12 hours (given every 12 hours)

Maximum dose limit:

• There is no strict limit on the Clexane 60mg dosage for this indication. However, dosing is based on the patient’s body weight. 

Missed Dose Instructions

• If a dose of Clexane 60 mg is missed, take it as soon as remembered. If it is very close to the next dose, skip the missed dose and just resume with the regular schedule. 

Overdose instructions: 

• Clinicians are recommended to use protamine sulfate in case of an overdose

ST-Elevation Myocardial Infarction (STEMI)

Recommended dose:

• 30 mg intravenous bolus + 1 mg/kg of Enoxaparin subcutaneously, followed by 1 mg/kg of Enoxaparin subcutaneously every 12 hours

Maximum dose limit:

• For the first two doses, the maximum limit is 100 mg Enoxaparin 
• The limit for further weight-based doses is determined based on the patient’s weight, tolerability to the drug, and response to the treatment.

Missed dose instructions: 

• In case of a missed dose, take the missed dose as soon as remembered. If the timing is close to the next dose, skip the missed dose and follow the normal schedule.

Overdose instructions: 

• Clinicians are recommended to use protamine sulfate in case of an overdose.

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How does Clexane 60 mg Work?

Clexane 60 mg is an anticoagulant (blood thinner) consisting of the drug Enoxaparin, which is a low molecular weight heparin that acts directly on several stages of the coagulation process.

In thrombotic states (when there is clot formation inside the blood vessels), various clotting factors work in a cascade reaction to create thrombin. Thrombin converts fibrinogen into fibrin, which leads to the development of a mature (stable) clot. Enoxaparin binds specifically to a factor, antithrombin III, which inhibits the activity of key clotting factors. By binding to antithrombin III, enoxaparin enhances its activity and inhibits Factor Xa, which is an enzyme that converts prothrombin (the inactive form of thrombin) to thrombin and thereby helps to generate more thrombin. 

Since enoxaparin can effectively bind to antithrombin III and inhibit its ability to form thrombin, the presence of enoxaparin decreases the amount of thrombin and, consequently, fibrin (which is formed from fibrinogen in the presence of thrombin) in the clot. In this way, Clexane 60 mg limits the growth of existing clots and prevents the formation of new clots. 

What are the Side Effects of Clexane 60 mg?

Common Side Effects

• Injection site pain, bruising, or redness
• Mild bleeding (e.g., nosebleeds, bleeding gums)
• Swelling at the injection site
• Anemia (low hemoglobin levels)
• Elevated liver enzymes

Less Common Side Effects

• Allergic reactions (rash, itching, urticaria)
• Headache
• Fever
• Peripheral edema (swelling of legs or arms)
• Diarrhea or nausea

Serious Side Effects

• Major bleeding (gastrointestinal, intracranial, or internal bleeding)
• Thrombocytopenia, including heparin-induced thrombocytopenia
• Spinal/epidural hematoma 
• Severe allergic reactions
• Skin necrosis at the injection site

Rare Side Effects

• Hyperkalemia
• Osteoporosis 
• Hair loss 
• Vasculitis 

When to Seek Immediate Medical Attention?

• Unusual or prolonged bleeding
• Black/tarry stools or blood in urine
• Severe headache or dizziness (possible brain bleed)
• Sudden weakness or numbness
• Difficulty breathing or swelling of the face/lips 

What are the Precautions Clexane 60 mg?

• Clexane 60 mg must be administered cautiously to patients with active bleeding, recent trauma, surgery, or peptic ulcers.
• There must be an appropriate dose adjustment for patients with renal impairment, hepatic impairment, and those with extremely high or low body weight.
• Avoid the consumption of Clexane 60 mg along with NSAIDs, antiplatelets, and other anticoagulants.
• While on Clexane 60 mg therapy, there must be regular monitoring of platelets, blood cell count, and potassium levels.
• For pregnant and lactating women, Clexane 60 mg should be administered cautiously.

Other Information

Frequently Asked Questions

1.How is Clexane 60 mg administered?

Hexane 60 is given through a subcutaneous infusion into the abdomen.

2.Can Clexane 60 mg cause bleeding?

Yes. Clexane 60 mg can increase the risk of bleeding.

3.Can I take painkillers with Clexane 60 mg?

Certain painkillers, like NSAIDs, are contraindicated with Clexane 60 mg.

4.Does Clexane 60 mg dissolve existing clots?

Clexane 60 mg can prevent the formation of new clots, but cannot dissolve existing clots.

5.What are the symptoms of Clexane 60 mg overdose?

Clexane 60 mg overdose can result in severe bleeding.