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Lenalid 25 mg Capsule
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Lenalidomide

Lenalid 25 mg Capsule

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What is the Lenalid 25 mg Capsule?

Lenalid 25 mg capsule treats certain blood cancers & related bone marrow disorders including multiple myeloma & myelodysplastic syndrome. It improves immune system to attack cancer cells and inhibits the new blood vessel formation that tumors need to grow to slow down its growth. Lenalid 25 mg Capsule consists of 25 mg of Lenalidomide, an immunomodulatory agen used in the treatment of certain cancers and syndromes. It works to promote the immune system and also controls the growth and proliferation of cancer cells. It may or may not be combined with other therapies based on the type of disorder treated.

 

 

What are the Uses of Lenalid 25 mg Capsule?

Lenalid 25 mg capsule is used in the treatment of Multiple Myeloma, Myelodysplastic Syndromes, Mantle Cell Lymphoma, Follicular Lymphoma & Marginal Zone Lymphoma as below;

 

Multiple Myeloma

Multiple myeloma is a form of cancer that originates in plasma cells found within the bone marrow where they begin to grow out of control. Lenalid 25 mg Capsule slows the proliferation of cancerous plasma cells, and enhances the capacity of immune-mediated destruction of cancer cells. It is used in combination with other medications, such as Dexamethasone.

Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are a group of disorders characterized by abnormal blood cells from the bone marrow, which leads to symptoms of anemia, fatigue, and a higher risk of becoming infected. Lenalid 25 mg Capsule improves bone marrow functioning, particularly in those patients with certain chromosomal defects, and increases the production of normal blood cells.

Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a form of aggressive non-Hodgkin lymphoma (NHL) that arises from B-lymphocytes and spreads quickly. Lenalid 25 mg Capsule is used as it affects MCL by suppressing the development and survival of lymphomas. It can also improve immunity against lymphoma..

Follicular Lymphoma

Follicular lymphoma (FL) is a slow-growing type of cancer formed from lymphocyte cells that usually enlarges lymph nodes and can relapse. Lenalid 25 mg Capsule is typically given with rituximab to improve immune function and reduce the patient's time in remission.

Marginal Zone Lymphoma

Marginal zone lymphoma (MZL) is an indolent lymphoma that involves B-cells from lymphoid tissues. Patients with relapsed MZL can be treated with Lenalid 25 mg Capsule, which improves the immune response and a direct inhibition of MZL cell growth. It is typically given with other therapies in patients receiving MZL.

What are the Dosage Guidelines for Lenalid 25 mg Capsule?

Lenalid 25 mg capsule is prescription anticancer medicine used to treat Multiple Myeloma, Myelodysplastic Syndromes, Mantle Cell Lymphoma, Follicular Lymphoma & Marginal Zone Lymphoma as below;

 

Multiple Myeloma

Myelodysplastic Syndromes

Mantle Cell Lymphoma

Follicular Lymphoma

Marginal Zone Lymphoma

 

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How does Lenalid 25 mg Capsule Work?

Lenalid 25 mg Capsule contains the active ingredient lenalidomide, a drug that supports various coordinated actions to inhibit the growth of cancer. Lenalidomide works primarily on the cancerous cells associated with certain disorders such as multiple myeloma, chronic lymphocytic leukemia, and lymphoblastic lymphoma. 

When the cells become malignant, they gain the ability to divide uncontrollably, avoid the immune system's detection, and stimulate blood vessel growth (angiogenesis) to support their survival. In advanced stages, these cells can spread to the surrounding parts of the organ, thus becoming difficult to treat.

At the molecular level, Lenalid 25 mg Capsule binds to the cereblon protein, which is a part of an intracellular protein-regulatory complex. This results in the destruction of specific transcription factors (Ikaros and Aiolos) that keep the malignant cell alive. These cells then lose the capacity to divide and are destroyed via "apoptosis" (programmed cell death).

Additionally, this drug also improves the immune response by enhancing T-cell and natural killer (NK) cell function, resulting in a greater capacity to identify and kill malignant cells. Lenalidomide inhibits pro-inflammatory cytokines (for example—TNF-alpha) that will aid the process of tumor growth.

Another major function of Lenalid 25 mg Capsule is its anti-angiogenic activity, i.e., inhibiting the development of new blood vessels that provide oxygen and nutrients to tumors. As a result, the tumor is starved of oxygen and blood vessels required for its growth and proliferation. In this way, through a multi-pronged approach, Lenalid 25 mg Capsule controls the growth of cancer.

What are the Side Effects of Lenalid 25 mg Capsule?

1. Very Common / Common Side Effects

The side effects in this section are most commonly experienced.

-→>Gastrointestinal:

-→>Musculoskeletal:

-→>Skin & General:

-→>Neurological:

-→>Blood-related (VERY important):

-→>Metabolic & Laboratory Changes

-→>Urinary & Reproductive

-→>Cardiovascular & Respiratory

-→>Infections

2. Serious / Dangerous Side Effects

The following symptoms require urgent medical attention:

-→>Blood Clots:

-→>Heart:

-→>Severe Skin Reactions:

-→>Liver Problems:

-→>Severe Allergic Reactions:

-→>Bone marrow suppression:

-→>Tumor-related:

-→>Neurological:

-→>Others:

3. Long-term / Rare Risks

What are the Precautions Lenalid 25 mg Capsule?

Other Information

Q. How long does Lenalid 25 mg therapy last?

The duration of Lenalid 25 mg therapy is decided by the medical care provider.

Q. Can Lenalid 25 mg Capsule be combined with other anticancer medicines?

Yes, it can be combined with other similar medicines. 

Q. Can Lenalid 25 mg Capsule be taken on an empty stomach?

Yes, Lenalid 25 mg Capsule be taken with or without food.

Q. Can Lenalid 25mg Capsule affect fertility?

This drug may affect the reproductive health in some individuals.

Q. Can I take vaccinations while on Lenalid therapy?

Live vaccinations should be avoided when under Lenalid 25mg therapy.

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