Lenvat 10mg Capsule

What is the Lenvat 10mg Capsule?

Lenvat 10mg Capsule is a high-quality product manufactured under strict quality control standards. Please consult with healthcare professional for specific information.

What are the Uses of Lenvat 10mg Capsule?

What are the Dosage Guidelines for Lenvat 10mg Capsule?

Differentiated Thyroid Cancer (Radioactive-iodine Refractory)

• Recommended doseof Lenvat 10mg Capsule: 24 mg of Lenvatinib once a day. (For this dosage, 2 tablets of Lenvat 10mg Capsule + another tablet making up 4 mg must be taken, depending on the formulation)
• Maximum dose of Lenvat 10mg Capsule: 24 mg per day
• Missed dose instructions for Lenvat 10mg Capsule: If a dose is missed, and less than 12 hours have passed since the previous dose, take it as soon as remembered. If the time lapsed is more than 12 hours, skip the missed dose and take the next scheduled dose.
• Overdose instructions: In case of an overdose, patients must immediately seek medical assistance. Taking a Lenvat 10 overdose can increase the risk of severe hypertension, kidney damage, heart complications, or severe gastrointestinal effects.

Advanced Renal Cell Carcinoma (Kidney Cancer)

For this indication, Lenvat 10mg Capsule is usually used with immunotherapy such as pembrolizumab.

• Recommended dose: 20 mg of Lenvatinib (2 tablets of Lenvat 10mg Capsule once a day
• Maximum dose: 20 mg per day
• Missed dose instructions for Lenvat 10mg Capsule: If a dose is missed, and less than 12 hours have passed since the previous dose, take it as soon as remembered. If the time lapsed is more than 12 hours, skip the missed dose and take the next scheduled dose.
• Overdose instructions for Lenvat 10mg Capsule: In case of an overdose, patients must immediately seek medical assistance. In case of overdose, monitoring of blood pressure, heart function, and kidney function may be required.

Unresectable Hepatocellular Carcinoma (Primary Liver Cancer)

For this indication, the dose depends on body weight.

• Recommended dose:
  • Patients less than 60 kg: 12 mg of Lenvatinib once a day (1 tablet Lenvat 10 + additional lower strength tablet)
  • Patients more than 60 kg: 8 mg of Lenvatinib once a day (Lower strength tablet required)
• Maximum dose: 12 mg of Lenvatinib per day
• Missed dose instructions: If a dose is missed, and less than 12 hours have passed since the previous dose, take it as soon as remembered. If the time lapsed is more than 12 hours, skip the missed dose and take the next scheduled dose.
• Overdose instructions: In case of an overdose, patients must immediately seek medical assistance. Immediate medical assistance is required as it may cause severe liver toxicity, bleeding, or dangerously high blood pressure.

Advanced Endometrial Cancer

For Lenvat 10mg Capsule, Levant 10 is usually used with immunotherapy such as pembrolizumab.

• Recommended dose: 20 mg of Lenvatinib (2 tablets of Lenvat 10) once a day
• Maximum dose: 20 mg of Lenvatinib per day
• Missed dose instructions: If a dose is missed, and less than 12 hours have passed since the previous dose, take it as soon as remembered. If the time lapsed is more than 12 hours, skip the missed dose and take the next scheduled dose.
• Overdose instructions:  In case of an overdose, patients must immediately seek medical assistance. Taking a Lenvat 10 overdose can increase the risk of severe hypertension, kidney damage, heart complications, or severe gastrointestinal effects.

Storage Guideline for Lenvat 10mg Capsule:

• Store Lenvat 10mg Capsules at room temperature (20°C–25°C / 68°F–77°F). Short-term temperature variations between 15°C and 30°C (59°F–86°F) are generally acceptable. 
• Keep Lenvat 10mg Capsules in their original blister pack or container until it is time to take a dose to protect them from moisture. 
• Store Lenvat 10 mg Capsules in a cool, dry place, away from direct sunlight, excessive heat, and humidity. 
• Do not store the capsules in the bathroom, near a sink, or in other damp environments. 
• Do not freeze the medication. 
• Keep out of the sight and reach of children and pets.

How does Lenvat 10mg Capsule Work?

Lenvat 10mg Capsule consists of 10 mg of its active ingredient Lenvatinib. This is an oral anticancer formulation that belongs to the class of multi-kinase inhibitors. Lenvat 10mg Capsule works by targeting several cell signalling pathways, which helps slow down tumor growth and progression.

Generally, cancer cells require a constant supply of nutrients and blood for their growth and proliferation. For this reason, the tumor cells form a network of blood vessels through a process called angiogenesis. Lenvat 10 works by blocking certain receptors involved in angiogenesis, particularly the vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3). In this way, Lenvat 10mg Capsule prevents the growth of the tumor by blocking the supply of blood and nutrients to it.

In addition to angiogenesis receptors, Levant also inhibits some tyrosine kinase receptors such as fibroblast growth factor receptors (FGFR-1 to FGFR-4), platelet-derived growth factor receptor (PDGFR-α), Receptor Tyrosine Kinase (RET), and receptor tyrosine kinase (KIT). These receptors signal cell growth and proliferation, and inhibiting these receptors prevents any further tumor growth.

Additionally, Lenvat 10mg Capsule also alters the microenvironment of the tumor, which further weakens the tumor's survival mechanisms. In this way, Levant 10mg Capsule uses a dual approach (inhibition of angiogenesis and growth signals) to control the progression of the tumor.

What are the Side Effects of Lenvat 10mg Capsule?

Very Common Side Effects of Lenvat 10mg Capsule

• High blood pressure (hypertension)
• Fatigue or extreme tiredness
• Diarrhea
• Nausea
• Vomiting
• Loss of appetite
• Weight loss
• Headache
• Muscle pain (myalgia)
• Joint pain (arthralgia)
• Abdominal pain
• Mouth sores (stomatitis)
• Hand-foot syndrome (redness, pain, peeling of palms and soles)
• Protein in urine (proteinuria)
• Hoarseness or voice changes (dysphonia)
• Skin rash
• Itching
• Hair loss
• Cough
• Constipation

Gastrointestinal Side Effects of Lenvat 10mg Capsule

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Heartburn or indigestion
• Stomach pain or tenderness
• Mouth ulcers
• Dry mouth
• Loss of appetite
• Gastrointestinal perforation (rare but serious)
• Gastrointestinal bleeding

Cardiovascular Side Effects of Lenvat 10mg Capsule

• High blood pressure
• Fast or irregular heartbeat
• Chest pain
• Heart failure
• Blood clots (arterial thromboembolic events)
• QT interval prolongation (heart rhythm abnormality)
• Swelling of arms, legs, or feet

Nervous System Side Effects of Lenvat 10mg Capsule

• Headache
• Dizziness
• Confusion
• Vision changes
• Seizures
• Reversible posterior leukoencephalopathy syndrome (rare brain disorder)

Respiratory Side Effects of Lenvat 10mg Capsule

• Cough
• Shortness of breath
• Hoarseness
• Nosebleeds
• Coughing up blood

Skin and Hair Side Effects of Lenvat 10mg Capsule

• Rash
• Itching
• Skin redness or peeling
• Hand-foot syndrome
• Hair loss
• Dry skin

Urinary and Kidney Side Effects of Lenvat 10mg Capsule

• Protein in urine
• Reduced urine output
• Kidney impairment or kidney failure
• Pain or burning during urination
• Urinary infections

Liver-Related Side Effects of Lenvat 10mg Capsule

• Elevated liver enzymes
• Hepatotoxicity (liver damage)
• Jaundice (yellowing of skin or eyes)
• Dark urine
• Pale stools

Hormonal / Metabolic Effects of Lenvat 10mg Capsule

• Abnormal thyroid function tests
• Electrolyte imbalance (low calcium, potassium, magnesium
• Dehydration

Blood and Bleeding Disorders

• Bleeding gums
• Nosebleeds
• Heavy menstrual bleeding
• Internal bleeding
• Blood in urine or stools

Other Possible Side Effects of Lenvat 10mg Capsule

• Fever
• Difficulty sleeping (insomnia)
• Depression or mood changes
• Jaw pain or dental problems
• Delayed wound healing
• Gallbladder or pancreatic inflammation
• Tumor fistula formation (rare)

What are the Precautions Lenvat 10mg Capsule?

• Lenvat 10mg Capsule must be consumed under strict medical supervision. Do not self medicate this drug.
• While on Lenvat 10, patients take regular blood pressure, kidney function, liver function, and urine tests.
• Patients must inform their healthcare providers in case they are suffering from, or have a history of heart disease, stroke, blood clots, or irregular heartbeat before starting Lenvat 10mg Capsule therapy.
• There is a risk of serious bleeding associated with this medication. Patients must immediately seek medical help if they experience any nosebleeds, blood in urine or stools, or coughing up blood.
• Apart from these, patients must immediately report any unusual symptoms like severe headache, chest pain, shortness of breath, severe abdominal pain, or sudden swelling.
• Lenvat 10mg Capsule can also delay wound healing significantly. Patients must inform their doctors about the ongoing Lenvat 10 therapy before undergoing any surgery or dental procedures.
• Avoid consuming Lenvat 10mg Capsule with any other drugs or herbal supplements without consulting the medical practitioner.

Other Information

• Q. How long does it take for Lenvat 10mg Capsule show effects?

It can take between a few weeks to several months for Lenvat to show significant effects.

• Q. Can Lenvat 10mg Capsule be taken without food?

Yes. Levant can be consumed with or without food.

• Q. Does Lenvat 10mg Capsule cause hair loss?

Hair thinning or hair loss is one of the common side effects of Lenvat.\

• Q. Can Lenvat 10mg Capsule be used during pregnancy?

No. Levant 10 must not be used during pregnancy as it can harm the developing fetus.

• Q. Does Lenvat 10mg Capsule cure cancer?

Lenvat 10mg Capsule can control the growth of cancer, but it cannot completely cure it.