Nindanib 100 Mg Capsule (Nintedanib) is a prescription medication and is used in the treatment of certain lung diseases and lung cancer. Nintedanib belongs to the class of tyrosine kinase inhibitors and works by inhibiting growth signals contributing to the etiology of these disorders. Nindanib 100 Mg Capsule slows down the progression of the disease and stabilizes lung function in the long term.
Idiopathic Pulmonary Fibrosis (IPF)
IPF is a chronic, progressive disease that occurs when the lung tissues become thick, stiff, and scarred over a period of time. As a result, the oxygen supply to the blood gradually reduces. This disease can slowly impair lung function over time and can even lead to respiratory failure. Nindanib 100 Mg Capsule works by slowing down the rate of lung tissue damage and overall decline of lung function. It is also effective in reducing the frequency of acute exacerbations (sudden episodes of worsening).
Chronic Fibrosing Interstitial Lung Diseases (Progressive ILDs)
This condition is a group of lung diseases arising due to inflammation and damage to the interstitium (supporting tissue of the lungs). ILDs can manifest due to a variety of causes and can behave similarly to IPF (gradual lung tissue damage). Nindanib 100 Mg Capsule is used for the treatment of progressive ILDs as it can mitigate the progression of the disease and preserve overall lung function. It is also one of the preferred medications, as ILD has very few treatment options due to progressive fibrosis.
Systemic Sclerosis-Associated ILD (SSc-ILD)
Systematic sclerosis occurs when the tissue from any organ becomes hard and stiff, specifically caused by autoimmunity. When this condition involves the lung, it is classified as interstitial lung disease, which is a fatal disease. Nindanib 100 Mg Capsule is administered as it can slow down disease progression and effectively preserve lung function.
Non-Small Cell Lung Cancer (NSCLC) – (Specific Cases)
NSCLC is the most common type of lung cancer, characterized by unregulated and uncontrolled cell proliferation in the lung airways and tissues. This disease has a high tendency to metastasize and can rapidly induce angiogenesis (formation of new blood vessels) to obtain a steady supply of oxygen and nutrients. For this condition, Nindanib 100 Mg Capsule is generally used when combined with chemotherapy (e.g., docetaxel). It controls the growth of the tumor and is generally preferred when initial treatments are ineffective.
The prescribed dosing for Nindanib 100 Mg Capsule is different for adult and child populations.
Approved Indications:
Dosing guidelines
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Nindanib 100 Mg Capsule (Nintedanib) is an anticancer drug that is used in the treatment of certain kinds of lung diseases, especially progressive lung diseases, and certain cancers. It mainly works by slowing down the progression of the disease rather than completely reversing the condition.
In lung conditions involving fibrosis, repeated microscopic injury to the lung tissue leads to an excessive fibroblast cell response. This response is brought about by the growth factors- VEGF, PDGF, and FGF. These factors interact with specific receptors on the fibroblast cells, which further trigger signalling pathways for fibroblast proliferation. This is an abnormal reaction, unlike the usual tissue repair process, which leads to a large amount of collagen deposition in the tissue, which further leads to stiff, scarred, and thickened lung tissue. These events manifest in the form of impaired lung function, inadequate supply of oxygen to the blood, and reduced lung elasticity.
Non-Small Cell Lung Cancer (NSCLC) cells produce factors like PDGF, FGF, and VEGF, which stimulate angiogenesis (the formation of new blood vessels) and cell proliferation, resulting in excess growth of the tumour and the formation of abnormal blood vessels in the lungs.
Nindanib 100 Mg Capsule is a triple angiokinase inhibitor that blocks the effects of these growth factors. This prevents the activation of the pathway responsible for activating fibroblasts in idiopathic pulmonary fibrosis which limits the excessive production of collagen in lung tissue. In this way, this drug slows down the progression of fibrosis, thus preserving the lung function for a longer period of time. In NSCLC, Nindanib 100 Mg Capsule prevents the angiogenesis activity, thus restricting the growth of the tumor further.
In essence, Nindanib 100 Mg Capsule mainly works by preventing any further damage to existing conditions, rather than reversing the underlying causes completely. This helps stabilize the physiological condition of the lungs and alleviate disease-related symptoms.
(Most frequently seen in patients)
Gastrointestinal
General / Others
Respiratory
Dermatological
Cardiovascular
Gastrointestinal
Hematologic
Hepatic
Endocrine
Nervous System
Musculoskeletal
Dermatological
General
Other (less severe but common in patients)
Cardiovascular
Gastrointestinal
Hepatic
Hematologic
Renal
Metabolic
Dermatological
Nindanib 100 Mg Capsule must only be consumed if prescribed by a licensed healthcare specialist.
1.What is the most common side effect caused by Nindanib 100 Mg Capsule?
The most common side effect associated with Nindanib 100 Mg Capsule is diarrhea.
2.Can the medicine be stopped after the symptoms are alleviated?
Nindanib 100 Mg Capsule must not be stopped abruptly as it can lead to recurrence.
3.Can Nindanib 100 Mg Capsule be consumed by pregnant women?
Nindanib 100 Mg Capsule must not be consumed by pregnant women as it can affect fetal growth.
4.Can Nindanib 100 Mg Capsule be taken with other drugs?
Consumption of Nindanib 100 Mg Capsule with other drugs must be decided by a medical specialist.
5.Does Nindanib 100 Mg Capsule cause any weight fluctuations?
Yes. There can be weight reduction in some cases, while on Nindanib 100 Mg Capsule therapy.
