Palbace 125mg Capsule is a prescription medicine prescribed with other hormonal anticancer therapies to treat hormone receptor-positive, HER2-negative breast cancer especially when the cancer has spread to other parts of the body, It is a CDK4/6 inhibitors class of medicine. Palbace 125mg Capsule is an oral anticancer formulation consisting of its active ingredient Palbociclib. Palbace 125mg Capsule mainly targets the cell cycle machinery of the cancer cells, It works by preventing the progression of the disease.
Palbace 125mg Capsule is used to treat different physiological types of breast cancers and control metastatic cancer. It works by inhibiting CDK4 and CDK6, (Cyclin-Dependent Kinases 4 and 6) proteins which help cancer cells grow and spread. It helps delay cancer progression by slowing down that cell cycle. It can be taken once a day for 21 days, followed by 7 days of rest in a 28-day cycle.
This is a type of breast cancer with a characteristic profile of receptors on the surface of tumor cells. These cells contain the receptors for estrogen, which is an essential component for tumor cell growth and proliferation. For this indication, Palbace 125mg Capsule is used in the treatment of this type of breast cancer, as it can effectively control the growth of cancer cells and prevent the spread of the tumor. Generally, it is used in combination with other medications such as Letrozole or Fulvestrant
Palbace 125mg Capsule is also used as a second-line therapy after the hormonal therapy proves to be ineffective. These cells have the receptors for estrogen; however, they continue to grow even in the absence of the hormone. These cells adapt alternate cell growth pathways and thus, bypass the requirement of estrogen, leading them to be unresponsive to hormonal therapy. For this indication. Palbace 125mg Capsule arrests the cell cycle of cancer cells, even through alternate cell division pathways, which controls the spread of the tumor.
Ovarian suppression is a treatment strategy used for hormone-receptor-positive breast cancers. These cancer cells take up estrogen for growth and metastasis. In younger women, the ovaries are the principal source of estrogen. Palbace 125mg Capsule is used to perform ovarian suppression to reduce the concentration of circulating estrogen, which creates a postmenopausal-like hormonal state. As a result, the amount of estrogen received by cancer cells is reduced, thus slowing down the progression of the disease.
This is the stage of breast cancer, where the tumor is still confined to the breast region. However, it has become too large or spread extensively, which makes it difficult to remove surgically. Palbace 125mg Capsule is used to control the spread and shrink the tumor. It can also be used as a supportive treatment before a surgical procedure.
Metastatic breast cancer, also known as stage IV cancer, is a condition of breast cancer where the tumor has spread out of the breast region to different tissues and organs. At this stage, the cancer cannot be cured, but can only be controlled. Palbace 125mg Capsule is used in the treatment of metastatic breast cancer as it can prevent the proliferation of cancer cells, thus controlling the disease.
The dosage of Palbace 125mg Capsule is similar for all the main indications mentioned above, as the biological profile for different indications is the same.
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Palbace 125mg Capsule is an oral targeted anticancer drug that consists of the active ingredient Palbociclib. It is used for the treatment of breast cancer that is hormone receptor-positive (HR+) and HER2-negative (HR+/HER2-) type.
HR+/HER2- breast cancer cells grow and divide in response to estrogen. This indicates that the primary target of this type of breast cancer is the overproduction of hormones such as estrogen. This causes the cancer to grow and proliferate rapidly. The growth and multiplication of HR+/HER2-breast cancer depend on 2 key proteins called cyclin-dependent kinases 4 & 6 (CDK4/6) that assist in the control of the cell cycle. These proteins assist the cell in progressing from the G1 phase (the period of time between the end of mitosis and the beginning of DNA replication) to the S phase (the period of time when DNA is being replicated).
When breast cancer cells are exposed to estrogen, they upregulate the synthesis of these proteins(CDK4/6), causing them to become overactive and rapidly phosphorylate the retinoblastoma protein (Rb). The Rb protein is the primary regulator of cell cycle progression. Therefore, when Rb is continuously phosphorylated, it no longer regulates the movement of the cell cycle from G1 to S, leading to uncontrolled cell proliferation or tumor growth.
Palbace 125mg Capsule selectively inhibits CDK4 and CDK6 to regain control of the cell cycle. By doing so, it blocks the phosphorylation of the Rb protein and keeps it in the active state. This active form of Rb continues to inhibit downstream signals that are needed for DNA replication. As a result, the cancer cell remains arrested in the G1 phase. Therefore, cancer cells cannot divide and remain in a non-proliferative state.
Palbace 125mg Capsule is often used in combination with hormonal therapies like Fulvestrant or aromatase inhibitors. With this approach, the benefits are magnified because hormonal therapy decreases the stimulation from estrogen, while Palbociclib inhibits the machinery needed for cell division. The combination of these two mechanisms creates a considerable slowing of tumor progression, a longer time before the disease worsens, and more positive clinical outcomes in the patient.
Possible SIde Effects of Palbace 125mg Capsule
1. Hematological (very common and clinically significant)
2. Infection-related
3. Gastrointestinal
4. General / Constitutional
5. Dermatological
6. Respiratory
7. Neurological
8. ENT (Ear, Nose, Throat)
9. Urinary
10. Eye-related
11. Bleeding-related
12. Oral and Mucosal
13. Metabolic / Nutritional
14. Hepatic
15. Reproductive
16. Hypersensitivity
17. Miscellaneous / Rare
Palbace 125mg Capsule should not be consumed by pregnant women as it can affect the developing fetus.
Palbace 125mg Capsule is mainly used in the treatment of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer, in combination with hormonal therapy.
Palbace 125mg Capsule mg is a targeted therapy, specifically a CDK4/6 inhibitor, and not a traditional chemotherapy for cancer.
The most common and critical side effects caused by Palbace 125mg Capsule are neutropenia (low white blood cell count).
The duration of Palbace 125mg Capsule must be determined by the healthcare provider, based on the patient’s condition, dose tolerability, and side effects.
