What is Renodapt S 180 mg
Renodapt S 180 mg (Mycophenolate sodium) is an immunosuppressive agent. It is mainly used to prevent the rejection of organ transplants, mainly kidney transplants. It works by controlling an excessive immune reaction of the host against the newly transplanted organ.
To Prevent Immunosuppression of Newly Transplanted Organs
The main challenge with organ transplant procedures is the rejection of the transplanted organ by the immune system of the host. In such cases, the host’s body perceives the organ as “foreign” or “non-self” and activates the immune system (T and B cells). As a result, an immune response is mounted against the organ, recruiting inflammatory signals towards it, thus causing tissue damage. Based on the type of immune reaction, there can be three main types of organ rejection:
1. Adult Kidney Transplant Patients
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The dosage of Renodapt S 180 mg is based on the patient’s Body Surface Area (BSA) and is calculated in mg/m² for pediatric dosing.
Recommended dose:
Maximum dose limit:
Missed dose instructions:
Overdose instructions:
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A patient receiving a kidney transplant develops an immune response against the new organ as the recipient's immune system recognizes the donor kidney as “foreign”. In such conditions, the helper T cells and B cells are activated and recruit large quantities of cytokines and antibodies. These responses lead to a state of inflammation, vascular damage, and destruction of cells of the transplanted kidney, resulting in rejection of the kidney transplant.
In this indication, Renodapt S 180 (mycophenolate sodium) works by inhibiting this excess immune reaction. When inside the body, the mycophenolate sodium is converted to mycophenolic acid (MPA), which selectively inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH). This enzyme is essential for the de novo synthesis of guanine nucleotides. T and B immune cells are mainly dependent on this pathway for DNA replication, as they are unable to use the "salvage pathways" like other cells of the body.
By inhibiting IMPDH, MPA reduces the amount of guanine nucleotides (necessary for cellular proliferation and DNA replication). This inhibition leads to a reduction of the clonal expansion of lymphocytes, decreased production of antibodies, and cytokine-mediated inflammation. As a result of these changes, the immune system has a diminished capacity to act against the transplanted organ, facilitating the efficient functioning and preventing rejection of the graft.
Very common
Common
Gastrointestinal (FDA emphasis)
Blood & lymphatic system
Infections
Skin & malignancy risk
Nervous system
Hypersensitivity reactions
Patients must take adequate preventive measures, as there is a risk of infections associated with this drug.
1.What are the indications treated using Renodapt S 180 mg?
Renodapt S 180 mg is mainly used for the prevention of kidney transplant rejection.
2.Can Renodapt S 180 mg be consumed on an empty stomach?
Yes, Renodapt S 180 mg must be consumed at least 1 hour before or 2 hours after food.
3.What are the most common side effects?
The most common side effects include diarrhoea, infections, low white blood cells, and abdominal pain.
4.Can Renodapt S 180 mg be consumed by pregnant women?
Renodapt S 180 mg must not be consumed by pregnant women as it is a potent teratogen.
5.Why is regular blood count monitoring required?
There is a risk of anemia due to Renodapt S 180 mg, which requires regular monitoring of blood count.
