Tacrotreat 1 mg Capsule is an immunosuppressive agent consisting of the active ingredient Tacrolimus. This drug is mainly used to support organ transplant procedures and autoimmune disorders (off-label). Tacrotreat 1 mg Capsule works by suppressing the T-lymphocyte proliferation in patients where the immune reaction is hostile or exaggerated.
To prevent rejection after an organ transplant
After organ transplant procedures, the host’s immune system can perceive the transplanted organ as “foreign” and mount an immune response against the transplanted organ. Tacrotreat 1 mg Capsule works by suppressing the undesirable immune response against the new organ (heart, liver, or kidney) and facilitating the new organ’s connection to the body.
Treatment after an organ transplant rejection
In some patients, there is immune rejection after receiving a transplanted organ despite using preventive measures. If left untreated, it may lead to inflammation of the transplanted organ, leading to failure of the transplant. Tacrotreat 1 mg Capsule can control this immune response against the transplanted organ and reverse the damaging effects of rejection.
Eczema (Atopic Dermatitis)
Atopic dermatitis is a chronic inflammatory skin condition mediated by the immune system. This results in skin lesions that are itchy, red, and dry. Tacrotreat 1 mg Capsule decreases the localised immune response in the skin, resulting in reduced symptoms while avoiding long-term side effects associated with steroid use.
Nephrotic Syndrome (Off-label use)
Nephrotic syndrome occurs when there is damage to the kidney's filtration units due to an abnormal immune reaction. Tacrotreat 1 mg Capsule helps suppress the immune-mediated damage to the kidneys, thus reducing protein loss from urine and improving kidney function.
Used for Autoimmune disorders as an off-label drug
1. Organ transplant (kidney/liver/heart) – prevention & treatment of rejection
2. Nephrotic Syndrome and Autoimmune Disorders (off-label)
3. Atopic Dermatitis (only topical use)
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During organ transplant procedures, the host’s immune system recognizes the transplanted organ or graft as “non-self” and activates the T-lymphocytes within the immune system. This leads to the release of inflammatory cytokines that mount a direct attack against the transplant, leading to graft rejection.
Similarly, these T-lymphocytes are also activated in autoimmune diseases, where they attack the “self” tissues, as if they were foreign, resulting in chronic inflammation and damage to these tissues.
Tacrolimus (Tacrotreat) binds to FK-binding protein (FKBP-12), which is a part of the intracellular signaling mechanism. This FKBP-12-tacrolimus complex inhibits an enzyme called calcineurin, which is responsible for the synthesis of the key cytokine interleukin 2 (IL-2). These cytokines promote the proliferation of T-lymphocytes, which are responsible for autoimmune response/organ transplant rejection.
By inhibiting calcineurin, Tacrotreat 1 mg Capsule suppresses the production of IL-2 and ultimately inhibits T-cell activation. This reduces the excess immune response and prevents graft rejection/ reduces the inflammation caused by autoimmunity.
Common side effects
Metabolic & systemic effects
Neurological side effects
Kidney & urinary effects
Cardiovascular effects
Infections & immunity-related
Hematological effects
Skin & hair changes
Serious/rare side effects (red flags)
Local (topical tacrolimus) side effects
1.Can Tacrotreat 1 mg Capsule be consumed with food?
Tacrotreat 1 mg Capsule can be consumed with or without food. However, the timings must be consistent.
2.What are the uses of Tacrotreat 1 mg Capsule ?
Tacrotreat 1 mg Capsule is mainly used for organ transplant procedures and certain autoimmune disorders (off-label).
3.Is Tacrotreat 1 mg Capsule safe in pregnancy?
Tacrotreat 1 mg Capsule must be prescribed to pregnant women only if absolutely required.
4.Can Tacrotreat 1 mg Capsule cause diabetes?
Yes. There is a risk of diabetes with long-term use of Tacrotreat 1 mg Capsule.
5.What are some red flag side effects of Tacrotreat1 mg Capsule?
Side effects like scanty urine output, persistent high fever, or severe confusion/tremors require immediate emergency care.
