Tagrisso 80 mg tablet is a prescription medicine used to treat non-small cell lung cancer (NSCLC) in adults with certain abnormal epidermal growth factor receptor. It works by blocking mutated EGFR proteins, including the T790M resistance mutation that helps to slow down & stop cancel cell growth & its spread, reduce tumor size & delay in disease progression. It is taken orally once daily with a water, with or without food as per the instructions given by your doctor.
Tagrisso 80 mg tablet is a adjuvant treatment prescribed after surgical removal of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) in eligible patients. It contains 80 mg of its active ingredient Osimertinib. It belongs to the class of tyrosine kinase inhibitors (TKIs) and works by blocking growth-promoting signals in cancer cells. Tagrisso 80 mg tablet is mainly used in the treatment of Non-Small Cell Lung Cancer (NSCLC) and its types.
Tagrisso 80 mg tablet is a first line treatment for epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) and also used for Resistant Cancer (T790M Mutation-Positive NSCLC), Lung Cancer with Brain Metastases treament & Adjuvant Therapy Following Surgical Resection in Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer (NSCLC) arises when lung cells proliferate without control, usually due to genetic changes. This tumor is caused by the EGFR gene, which becomes overactive and constantly signals cell proliferation. Tagrisso 80 Tagrisso 80 mg tablet is an initial (first-line) treatment option for cancers caused by excess EGFR activity. This can result in reduced tumor size, slowed or halted tumor growth, and significant delays in progression of the disease.
For this condition, patients initially receive one of the older EGFR-targeted therapies, but eventually, there might be some mutations that can make the cancer resistant to such therapies. Tagrisso 80 Tagrisso 80 mg tablet can bind and block the mutated receptor, allowing it to be effective for patients who have progressed beyond prior therapies.
In patients with early-stage lung cancer, initially, the visible tumor is attempted to be removed surgically(i.e., lobectomy or wedge resection). Even after a successful operation, cancer cells may remain in the patient's body and can go undetected by conventional means. These cancer cells can grow back and cause disease recurrence. Tagrisso 80 mg tablet is given as adjuvant treatment after surgery and is specifically used in patients with EGFR mutation types to eliminate any residual cancer cells.
Lung cancers that have progressed to advanced stages have a tendency to metastasize to the brain. Due to the blood-brain barrier, many chemotherapy medications do not adequately penetrate the brain and thus are less effective for treating patients who have lung cancer with brain metastases. Tagrisso 80 mg tablet has the ability to cross the blood-brain barrier, and thus, it can control both lung and brain cancers effectively.
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Tagrisso 80 mg tablet (Osimertinib) is an anti-cancer therapy designed primarily to treat certain forms of Non-Small Cell Lung Cancer. Tagrisso 80 mg tablet provides a targeted means of cancer treatment compared to traditional chemotherapies, as the latter may damage both healthy and cancer cells. However, this specific type of drug is designed to target only cancer cells with specific genetic characteristics and, therefore, may be tolerated better than more traditional forms of chemotherapy by patients who will receive it.
EGFR is one of the critical genes involved in the proliferation of non-small-cell lung cancer. Healthy cells in the body typically use EGFR to regulate their growth and proliferation. However, in some cases, EGFR undergoes a genetic mutation that keeps it permanently activated. Therefore, the mutated EGFR continuously signals the cells to rapidly grow, proliferate, and metastasize to other areas of the body. In addition, over time, a sub-population of patients may develop an additional mutation of the gene EGFR (the T790M mutation), which renders prior anti-EGFR therapies ineffective.
Tagrisso 80 mg tablet inhibits and blocks this abnormal EGFR protein by specifically binding to the mutated receptor and preventing it from signaling. This stops the cancer from growing and responding to the signals it receives from the receptor. In addition to blocking the common activating EGFR mutations, Tagrisso 80 mg tablet is also effective in blocking the T790M resistance mutation. By targeting the common activating and T790M EGFR mutations, Tagrisso 80 mg tablet has minimal effect on normal cells, thereby slowing the growth of tumors, decreasing the size of existing tumors, and delaying the progression of the disease.
Tagrisso 80 mg tablet also has the ability to cross the blood-brain barrier to reach cancer cells that have spread to the brain. By interrupting the cancer’s growth signals at their source, Osimertinib allows for more effective and longer-lasting control of the disease.
Listed below are some of the most frequently seen:
– >Hematological (blood-related)
(The side effects listed below require immediate medical attention.)
– >Lung toxicity
– >Heart-related
– >Severe skin reactions
Tagrisso 80 mg tablet must be consumed only if prescribed by a qualified oncologist.
Q. What is Tagrisso 80 mg tablet used for?
Tagrisso 80 mg tablet is mainly used in the treatment of non-small cell lung cancer and its variations.
Q. What is the duration of Tagrisso therapy?
The duration of Tagrisso therapy must be decided by the healthcare provider.
Q. What are the most common side effects?
Typical side effects observed after taking Tagrisso 80 mg tablet include diarrhea, rash, dry skin, nail changes, and fatigue.
Q. Can Tagrisso 80 mg tablet affect the heart?
Tagrisso 80 mg tablet can present cardiac signs such as QT prolongation or heart weakness in some patients.
Q. Can pregnant women take Tagrisso 80 mg tablet?
Tagrisso 80 mg tablet must not be consumed by pregnant women as it can affect the developing fetus.
